Antinuclear antibodies and juvenile chronic arthritis (JCA): search for a specific autoantibody associated with JCA.
نویسندگان
چکیده
منابع مشابه
Autoantibodies in chronic arthritis of childhood: relations with each other and with histocompatibility antigens.
BACKGROUND Studies have shown the presence of either antibodies to histone or anticardiolipin antibodies in some forms of childhood chronic arthritis. The relation between these autoantibodies has not been previously reported, however, and the immunogenetics of their association with childhood arthritis has not been studied. METHODS The interrelation of fluorescent antinuclear antibodies, ant...
متن کاملAutoantibody profile in juvenile chronic arthritis.
Patients with juvenile chronic arthritis (JCA) may be subdivided into a minority, who carry IgM rheumatoid factor and have erosive polyarthritis resembling adult rheumatoid arthritis, and the majority (90%), who are seronegative by conventional means. Between 30 and 60% of patients with JCA have positive antinuclear antibodies (ANAs) according to the choice of substrate for indirect immunofluor...
متن کاملScreening for uveitis in juvenile chronic arthritis.
Three hundred and fifteen patients with anterior uveitis associated with juvenile chronic arthritis (JCA) were studied in order to identify the various risk factors for uveitis. Girls were more susceptible to uveitis than boys by a ratio of 3:1. In 94% of cases the uveitis was diagnosed after the development of arthritis. The risk of uveitis was small after seven or more years had elapsed from ...
متن کاملAetiological role of bacteria associated with reactive arthritis in pauciarticular juvenile chronic arthritis.
BACKGROUND The cause of juvenile chronic arthritis (JCA) is unknown. Pauciarticular JCA is the most common subtype and can be subdivided into early (type I) and late onset (type II) forms, the latter clinically resembling reactive arthritis. METHODS The cellular immune responses to bacteria associated with reactive arthritis in blood and synovial fluid from 39 children with pauciarticular JCA...
متن کاملAutoantibodies in patients with juvenile chronic arthritis and their immediate family relatives.
Antibodies to nuclear antigens were assessed in 23 children with juvenile chronic arthritis (JCA) and 66 of their first degree relatives. Serum samples from 16 patients with JCA (70%) and nine relatives (14%) had antinuclear antibodies by indirect immunofluorescence. Antibodies against nuclear antigens in rabbit thymus extract or an erythroblastoid cell line (K562) were detected by countercurre...
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عنوان ژورنال:
- Annals of the rheumatic diseases
دوره 50 9 شماره
صفحات -
تاریخ انتشار 1991